[HTML][HTML] Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation
Y Liu, H Liu, C Meyer, J Li, S Nadalin… - Journal of Biological …, 2013 - ASBMB
In fibrotic liver, connective tissue growth factor (CTGF) is constantly expressed in activated
hepatic stellate cells (HSCs) and acts downstream of TGF-β to modulate extracellular matrix
production. Distinct from other cell types in which Smad signaling plays major role in
regulating CTGF production, TGF-β stimulated CTGF expression in activated HSCs is only in
part dependent on Smad3. Other signaling molecules like MAPKs and PI3Ks may also
participate in this process, and the underlying mechanisms have yet to be clarified. In this …
hepatic stellate cells (HSCs) and acts downstream of TGF-β to modulate extracellular matrix
production. Distinct from other cell types in which Smad signaling plays major role in
regulating CTGF production, TGF-β stimulated CTGF expression in activated HSCs is only in
part dependent on Smad3. Other signaling molecules like MAPKs and PI3Ks may also
participate in this process, and the underlying mechanisms have yet to be clarified. In this …