Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells
E Morán-Salvador, E Titos, B Rius… - Journal of …, 2013 - Elsevier
Background & Aims PPARγ plays an essential role in the transcriptional regulation of genes
involved in lipid and glucose metabolism, insulin sensitivity, and inflammation. We recently
demonstrated that PPARγ plays a causative role in hepatocyte lipid deposition, contributing
to the pathogenesis of hepatic steatosis. In this study, we investigated the role of PPARγ in
the inflammatory and fibrogenic response of the liver. Methods Heterozygous floxed/null
Cre/LoxP mice with targeted deletion of PPARγ in either hepatocytes (Alb-Cre) …
involved in lipid and glucose metabolism, insulin sensitivity, and inflammation. We recently
demonstrated that PPARγ plays a causative role in hepatocyte lipid deposition, contributing
to the pathogenesis of hepatic steatosis. In this study, we investigated the role of PPARγ in
the inflammatory and fibrogenic response of the liver. Methods Heterozygous floxed/null
Cre/LoxP mice with targeted deletion of PPARγ in either hepatocytes (Alb-Cre) …