[HTML][HTML] Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis
A Krishnan, X Li, WWY Kao, K Viker, K Butters… - Laboratory …, 2012 - Elsevier
Lumican, an extracellular matrix proteoglycan was previously shown to be upregulated with
increasing severity of nonalcoholic steatohepatitis (NASH). Although lumican is involved in
collagen fibrillogenesis in extra-hepatic tissues, little is known about the role of lumican in
hepatic disease. We therefore determined lumican expression in etiologies other than
clinical NASH. Our results indicated that lumican is upregulated in clinical samples of
hepatitis C virus infection, in experimental rodent models of chronic and acute liver injury …
increasing severity of nonalcoholic steatohepatitis (NASH). Although lumican is involved in
collagen fibrillogenesis in extra-hepatic tissues, little is known about the role of lumican in
hepatic disease. We therefore determined lumican expression in etiologies other than
clinical NASH. Our results indicated that lumican is upregulated in clinical samples of
hepatitis C virus infection, in experimental rodent models of chronic and acute liver injury …
