[HTML][HTML] Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Y Takahashi, Y Soejima, T Fukusato - World journal of …, 2012 - ncbi.nlm.nih.gov
Y Takahashi, Y Soejima, T Fukusato
World journal of gastroenterology: WJG, 2012ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in
the liver of a patient without a history of alcohol abuse. Nonalcoholic steatohepatitis (NASH),
a severe form of NAFLD, can progress to liver cirrhosis and hepatocellular carcinoma.
NAFLD is regarded as a hepatic manifestation of metabolic syndrome and incidence has
been increasing worldwide in line with the increased prevalence of obesity, type 2 diabetes,
and hyperlipemia. Animal models of NAFLD/NASH give crucial information, not only in …
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient without a history of alcohol abuse. Nonalcoholic steatohepatitis (NASH), a severe form of NAFLD, can progress to liver cirrhosis and hepatocellular carcinoma. NAFLD is regarded as a hepatic manifestation of metabolic syndrome and incidence has been increasing worldwide in line with the increased prevalence of obesity, type 2 diabetes, and hyperlipemia. Animal models of NAFLD/NASH give crucial information, not only in elucidating pathogenesis of NAFLD/NASH but also in examining therapeutic effects of various agents. An ideal model of NAFLD/NASH should correctly reflect both hepatic histopathology and pathophysiology of human NAFLD/NASH. Animal models of NAFLD/NASH are divided into genetic, dietary, and combination models. In this paper, we review commonly used animal models of NAFLD/NASH referring to their advantages and disadvantages.
ncbi.nlm.nih.gov