Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease
AD Lake, P Novak, CD Fisher, JP Jackson… - Drug metabolism and …, 2011 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is characterized by a series of pathological
changes that range from simple fatty liver to nonalcoholic steatohepatitis (NASH). The
objective of this study is to describe changes in global gene expression associated with the
progression of human NAFLD. This study is focused on the expression levels of genes
responsible for the absorption, distribution, metabolism, and elimination (ADME) of drugs.
Differential gene expression between three clinically defined pathological groups—normal …
changes that range from simple fatty liver to nonalcoholic steatohepatitis (NASH). The
objective of this study is to describe changes in global gene expression associated with the
progression of human NAFLD. This study is focused on the expression levels of genes
responsible for the absorption, distribution, metabolism, and elimination (ADME) of drugs.
Differential gene expression between three clinically defined pathological groups—normal …
