[HTML][HTML] Different functional and structural characteristics between ApoA-I and ApoA-4 in lipid-free and reconstituted HDL state: ApoA-4 showed less anti-atherogenic …
Apolipoprotein AI and A-IV are protein constituents of high-density lipoproteins although
their functional difference in lipoprotein metabolism is still unclear. To compare anti-
atherogenic properties between apoA-I and apoA-4, we characterized both proteins in lipid-
free and lipid-bound state. In lipid-free state, apoA4 showed two distinct bands, around 78
and 67 Å on native gel electrophoresis, while apoA-I showed scattered band pattern less
than 71 Å. In reconstituted HDL (rHDL) state, apoA-4 showed three major bands around 101 …
their functional difference in lipoprotein metabolism is still unclear. To compare anti-
atherogenic properties between apoA-I and apoA-4, we characterized both proteins in lipid-
free and lipid-bound state. In lipid-free state, apoA4 showed two distinct bands, around 78
and 67 Å on native gel electrophoresis, while apoA-I showed scattered band pattern less
than 71 Å. In reconstituted HDL (rHDL) state, apoA-4 showed three major bands around 101 …
