[HTML][HTML] Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1
We showed recently that apoA-IV improves glucose homeostasis by enhancing pancreatic
insulin secretion in the presence of elevated levels of glucose. Therefore, examined whether
apolipoprotein A-IV (apoA-IV) also regulates glucose metabolism through the suppression of
hepatic gluconeogenesis. The ability of apoA-IV to lower gluconeogenic gene expression
and glucose production was measured in apoA-IV−/− and wild-type mice and primary
mouse hepatocytes. The transcriptional regulation of Glc-6-Pase and phosphoenolpyruvate …
insulin secretion in the presence of elevated levels of glucose. Therefore, examined whether
apolipoprotein A-IV (apoA-IV) also regulates glucose metabolism through the suppression of
hepatic gluconeogenesis. The ability of apoA-IV to lower gluconeogenic gene expression
and glucose production was measured in apoA-IV−/− and wild-type mice and primary
mouse hepatocytes. The transcriptional regulation of Glc-6-Pase and phosphoenolpyruvate …