In vivo metabolism of apolipoproteins A-IV and AI associated with high density lipoprotein in normolipidemic subjects

CL Malmendier, JF Lontie, L Lagrost, C Delcroix… - Journal of lipid …, 1991 - ASBMB
The kinetics of apolipoprotein A-IV associated with high density lipoproteins (HDL) of
plasma from fasting human subjects was followed for 15 days in five healthy normolipidemic
volunteers. Purified apoA-IV and apoA-I were radioiodinated, respectively, with 125I and
131I, incubated in vitro with normal HDL, isolated at density 1.250 g/ml, and finally reinjected
intravenously as HDL-125I-labeled apoA-IV and HDL-131I-labeled apoA-I. Blood samples
were withdrawn at regular intervals for 15 days, and 24-h urine samples were collected …