[HTML][HTML] Apolipoprotein A-II alters the proteome of human lipoproteins and enhances cholesterol efflux from ABCA1
JT Melchior, SE Street, AB Andraski, JD Furtado… - Journal of lipid …, 2017 - ASBMB
HDLs are a family of heterogeneous particles that vary in size, composition, and function.
The structure of most HDLs is maintained by two scaffold proteins, apoA-I and apoA-II, but
up to 95 other" accessory" proteins have been found associated with the particles. Recent
evidence suggests that these accessory proteins are distributed across various subspecies
and drive specific biological functions. Unfortunately, our understanding of the molecular
composition of such subspecies is limited. To begin to address this issue, we separated …
The structure of most HDLs is maintained by two scaffold proteins, apoA-I and apoA-II, but
up to 95 other" accessory" proteins have been found associated with the particles. Recent
evidence suggests that these accessory proteins are distributed across various subspecies
and drive specific biological functions. Unfortunately, our understanding of the molecular
composition of such subspecies is limited. To begin to address this issue, we separated …