[HTML][HTML] Zinc fingers and homeoboxes 2 is required for diethylnitrosamine‐induced liver tumor formation in C57BL/6 mice
J Jiang, C Turpin, GS Qiu, M Xu, E Lee… - Hepatology …, 2022 - journals.lww.com
Liver cancer, comprised primarily of hepatocellular carcinoma (HCC), is the third leading
cause of cancer deaths worldwide and increasing in Western countries. We previously
identified the transcription factor zinc fingers and homeoboxes 2 (Zhx2) as a regulator of
hepatic gene expression, and many Zhx2 target genes are dysregulated in HCC. Here, we
investigate HCC in Zhx2‐deficient mice using the diethylnitrosamine (DEN)–induced liver
tumor model. Our study using whole‐body Zhx2 knockout (Zhx2 KO) mice revealed the …
cause of cancer deaths worldwide and increasing in Western countries. We previously
identified the transcription factor zinc fingers and homeoboxes 2 (Zhx2) as a regulator of
hepatic gene expression, and many Zhx2 target genes are dysregulated in HCC. Here, we
investigate HCC in Zhx2‐deficient mice using the diethylnitrosamine (DEN)–induced liver
tumor model. Our study using whole‐body Zhx2 knockout (Zhx2 KO) mice revealed the …