[HTML][HTML] Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for …

SA Kornilov, I Lucas, K Jade, CL Dai, JC Lovejoy… - Critical care, 2020 - Springer
SA Kornilov, I Lucas, K Jade, CL Dai, JC Lovejoy, AT Magis
Critical care, 2020Springer
To the Editor: Patients at high risk for mortality from COVID-19, the disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are more likely to be older
and male and have chronic diseases such as hypertension, diabetes, cardiovascular, and
chronic lung disease [1, 2]. Although the mechanisms behind these associations are poorly
understood, this increased risk could be partly associated with increased expression of the
cellular receptor of SARS-CoV-2, angiotensin-converting enzyme-2, found at elevated levels …
To the Editor: Patients at high risk for mortality from COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are more likely to be older and male and have chronic diseases such as hypertension, diabetes, cardiovascular, and chronic lung disease [1, 2]. Although the mechanisms behind these associations are poorly understood, this increased risk could be partly associated with increased expression of the cellular receptor of SARS-CoV-2, angiotensin-converting enzyme-2, found at elevated levels in older individuals, men, and in cardiovascular and inflammatory conditions [3, 4]. It maintains homeostasis of the renin-angiotensin system and converts angiotensin II to angiotensin 1-7, which has vasodilatory and anti-inflammatory properties. The membrane-bound form (mACE2) is highly expressed in the heart, airways, kidney, and liver tissue, and the enzymatically active soluble form (sACE2) is generated in response to inflammatory signals and disease via mACE2 shedding.
Springer