[HTML][HTML] Organoid: a powerful tool to study lung regeneration and disease
T Lu, Y Cao, P Zhao, S Shen, Y Xi - Cell Regeneration, 2021 - Springer
T Lu, Y Cao, P Zhao, S Shen, Y Xi
Cell Regeneration, 2021•SpringerOrganoids are three-dimensional self-organizing structures formed by adult tissue stem cells
or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue
development, homeostasis, regeneration and disease, and provide an in vitro model for
drug screening. This review summarizes the recent advances of organoid cultures derived
from adult lung stem cells and human pluripotent stem cells, especially focusing on the
organoids of the distal airway stem/progenitor cells. We also discuss the applications of …
or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue
development, homeostasis, regeneration and disease, and provide an in vitro model for
drug screening. This review summarizes the recent advances of organoid cultures derived
from adult lung stem cells and human pluripotent stem cells, especially focusing on the
organoids of the distal airway stem/progenitor cells. We also discuss the applications of …
Abstract
Organoids are three-dimensional self-organizing structures formed by adult tissue stem cells or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue development, homeostasis, regeneration and disease, and provide an in vitro model for drug screening. This review summarizes the recent advances of organoid cultures derived from adult lung stem cells and human pluripotent stem cells, especially focusing on the organoids of the distal airway stem/progenitor cells. We also discuss the applications of organoids in studying lung regeneration and pulmonary diseases, including pulmonary fibrosis, airway diseases and Coronavirus disease 2019 (COVID-19).
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