Circulating HLA-DR+ natural killer cells have potent lytic ability and weak antigen-presenting cell function
BM Burt, G Plitas, HM Nguyen, JA Stableford… - Human immunology, 2008 - Elsevier
Whether a freshly isolated immune cell can be equipped with both natural killing and
antigen-presenting cell (APC) function has recently become controversial in mice. We
sought to probe the existence of a candidate human cell with these properties by searching
for cells in healthy subjects that co-express APC surface molecules and NK cell receptors.
We have found that CD3− CD14− CD19− mononuclear cells of human blood, spleen, liver,
and lymph nodes contain two distinct populations of cells that co-express HLA-DR (DR) and …
antigen-presenting cell (APC) function has recently become controversial in mice. We
sought to probe the existence of a candidate human cell with these properties by searching
for cells in healthy subjects that co-express APC surface molecules and NK cell receptors.
We have found that CD3− CD14− CD19− mononuclear cells of human blood, spleen, liver,
and lymph nodes contain two distinct populations of cells that co-express HLA-DR (DR) and …