[HTML][HTML] Thrombospondin-4 mediates cardiovascular remodelling in angiotensin II-induced hypertension
T Palao, L Medzikovic, C Rippe, S Wanga… - Cardiovascular …, 2018 - Elsevier
Abstract Thrombospondin 4 (TSP-4) expression is induced in the heart and vasculature
under pathological conditions, including myocardial infarction, myocardial pressure
overload, and hypertension. TSP-4 is linked to remodelling processes, where it may affect
extracellular matrix protein organization. In previous work, we studied the role of TSP-4 in
small arteries during hypertension using Ang II-treated Thrombospondin 4 knockout
(Thbs4−/−) mice. We reported increased heart weight, as well as the occurrence of aortic …
under pathological conditions, including myocardial infarction, myocardial pressure
overload, and hypertension. TSP-4 is linked to remodelling processes, where it may affect
extracellular matrix protein organization. In previous work, we studied the role of TSP-4 in
small arteries during hypertension using Ang II-treated Thrombospondin 4 knockout
(Thbs4−/−) mice. We reported increased heart weight, as well as the occurrence of aortic …