[CITATION][C] [39] Tetanus and botulism neurotoxins: Isolation and assay
G Schiavo, C Montecucco - Methods in enzymology, 1995 - Elsevier
The paralysis associated with tetanus and botulism is caused by neurotoxins produced by
bacteria of the genus Clostridium. These are the most powerful toxins known, the LD50 in
mice being in the range 0.1-1 ng/kg. Tetanus neurotoxin (TENT) is produced by toxigenic
strains of Clostridium tetani in a single type, whereas seven different serotypes (A, B, C, D, E,
F, and G) of botulism neurotoxin (BoNT) are made by Clostridium botulihum and other
clostridia, a-3 The neurotoxins have a similar structural organization. They are synthesized …
bacteria of the genus Clostridium. These are the most powerful toxins known, the LD50 in
mice being in the range 0.1-1 ng/kg. Tetanus neurotoxin (TENT) is produced by toxigenic
strains of Clostridium tetani in a single type, whereas seven different serotypes (A, B, C, D, E,
F, and G) of botulism neurotoxin (BoNT) are made by Clostridium botulihum and other
clostridia, a-3 The neurotoxins have a similar structural organization. They are synthesized …