Sorbitol dehydrogenase of drosophila: gene, protein, and expression data show a two-gene system
T Luque, L Hjelmqvist, G Marfany, O Danielsson… - Journal of Biological …, 1998 - jbc.org
The Drosophila melanogaster sorbitol dehydrogenase (SDH) is characterized as a two-
enzyme system of the medium chain dehydrogenase/reductase family (MDR). The SDH-1
enzyme has an enzymology with K m andk cat values an order of magnitude higher than
those for the human enzyme but with a similark cat/K m ratio. It is a tetramer with identical
subunits of∼ 38 kDa. At the genomic level, two genes, Sdh-1 and Sdh-2, have a single
transcriptional start site and no functional TATA box. Expression is greater in larvae and …
enzyme system of the medium chain dehydrogenase/reductase family (MDR). The SDH-1
enzyme has an enzymology with K m andk cat values an order of magnitude higher than
those for the human enzyme but with a similark cat/K m ratio. It is a tetramer with identical
subunits of∼ 38 kDa. At the genomic level, two genes, Sdh-1 and Sdh-2, have a single
transcriptional start site and no functional TATA box. Expression is greater in larvae and …