Role of aldose reductase in the development of diabetes-associated complications
PF Kador, JH Kinoshita - The American journal of medicine, 1985 - Elsevier
The aldose reductase-initiated intracellular accumulation of polyols has been clearly shown
to have a hyperosmotic effect on the lens of experimental animals. Similar localized osmotic
changes resulting in the onset of pathology may also occur in the nerve, corneal epithelium,
and retinal pericytes. Except for experimental diabetic cataracts, however, the exact
mechanism by which aldose reductase is involved in these diabetes-associated
complications remains to be clarified.
to have a hyperosmotic effect on the lens of experimental animals. Similar localized osmotic
changes resulting in the onset of pathology may also occur in the nerve, corneal epithelium,
and retinal pericytes. Except for experimental diabetic cataracts, however, the exact
mechanism by which aldose reductase is involved in these diabetes-associated
complications remains to be clarified.