[HTML][HTML] Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism
BCJ van der Eerden, WNH Koek, P Roschger… - Oncotarget, 2016 - ncbi.nlm.nih.gov
BCJ van der Eerden, WNH Koek, P Roschger, MC Zillikens, JH Waarsing, A van der Kemp…
Oncotarget, 2016•ncbi.nlm.nih.govTrpv5 plays an important role in calcium (Ca 2+) homeostasis, among others by mediating
renal calcium reabsorption. Accordingly, Trpv5 deficiency strongly stresses Ca 2+
homeostasis in order to maintain stable serum Ca 2+. We addressed the impact of lifelong
challenge of calcium homeostasis on the bone phenotype of these mice.
renal calcium reabsorption. Accordingly, Trpv5 deficiency strongly stresses Ca 2+
homeostasis in order to maintain stable serum Ca 2+. We addressed the impact of lifelong
challenge of calcium homeostasis on the bone phenotype of these mice.
Abstract
Trpv5 plays an important role in calcium (Ca 2+) homeostasis, among others by mediating renal calcium reabsorption. Accordingly, Trpv5 deficiency strongly stresses Ca 2+ homeostasis in order to maintain stable serum Ca 2+. We addressed the impact of lifelong challenge of calcium homeostasis on the bone phenotype of these mice.
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