Influence of Dietary Phosphate on Bone Resorption in Senescent Mice1
GVG Krishnarao, HH Draper - The Journal of Nutrition, 1972 - jn.nutrition.org
The influence of dietary phosphate on bone resorption was investigated in adult mice fed a
high calcium diet. Nine-month-old mice were fed a diet containing 1.2% Ca and either 0.6%
or 1.2% P for 16 months. At 25 months of age the femurs of the animals fed the higher
phosphorus diet exhibited a lower breaking strength and a reduced content of ash, calcium,
and phosphorus. This accelerated rate of bone resorption was arrested by lowering the
phosphorus content of the diet from 1.2% to 0.6% at 18 months of age. The exacerbating …
high calcium diet. Nine-month-old mice were fed a diet containing 1.2% Ca and either 0.6%
or 1.2% P for 16 months. At 25 months of age the femurs of the animals fed the higher
phosphorus diet exhibited a lower breaking strength and a reduced content of ash, calcium,
and phosphorus. This accelerated rate of bone resorption was arrested by lowering the
phosphorus content of the diet from 1.2% to 0.6% at 18 months of age. The exacerbating …
