Effects of dietary phosphate and calcium intake on fibroblast growth factor-23
MG Vervloet, FJ van Ittersum, RM Büttler… - Clinical Journal of the …, 2011 - journals.lww.com
Results Serum phosphate levels and urinary phosphate increased during high dietary
phosphate intake (from 1.11 to 1.32 mmol/L, P< 0.0001 and 21.6 to 28.8 mmol/d, P= 0.0005,
respectively). FGF23 serum levels increased during high dietary phosphate/calcium intake
(cFGF23 from 60 to 72 RU/ml, P< 0.001; iFGF23 from 33 to 37 ng/L, P= 0.003), whereas PTH
declined. 1, 25-Dihydroxyvitamin D (1, 25D) showed an inverse relation with FGF23.
Conclusions Variation in dietary phosphate and calcium intake induces changes in FGF23 …
phosphate intake (from 1.11 to 1.32 mmol/L, P< 0.0001 and 21.6 to 28.8 mmol/d, P= 0.0005,
respectively). FGF23 serum levels increased during high dietary phosphate/calcium intake
(cFGF23 from 60 to 72 RU/ml, P< 0.001; iFGF23 from 33 to 37 ng/L, P= 0.003), whereas PTH
declined. 1, 25-Dihydroxyvitamin D (1, 25D) showed an inverse relation with FGF23.
Conclusions Variation in dietary phosphate and calcium intake induces changes in FGF23 …