Osteopontin regulation by inorganic phosphate is ERK1/2-, protein kinase C-, and proteasome-dependent
GR Beck, N Knecht - Journal of Biological Chemistry, 2003 - jbc.org
The generation of inorganic phosphate by alkaline phosphatase during osteoblast
differentiation represents an important signaling event, although the molecular and cellular
consequences are currently undefined. We have previously described osteopontin as a
gene regulated by an increase in inorganic phosphate not only in osteoblasts but also in
other cell types. We describe here the identification of specific signaling pathways required
for the stimulation of osteopontin expression by inorganic phosphate. We have determined …
differentiation represents an important signaling event, although the molecular and cellular
consequences are currently undefined. We have previously described osteopontin as a
gene regulated by an increase in inorganic phosphate not only in osteoblasts but also in
other cell types. We describe here the identification of specific signaling pathways required
for the stimulation of osteopontin expression by inorganic phosphate. We have determined …