[HTML][HTML] Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo
NM Gharavi, JA Alva, KP Mouillesseaux, C Lai… - Journal of Biological …, 2007 - ASBMB
Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its
component phospholipid, 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine,
induce endothelial cells (EC) to synthesize chemotactic factors, such as interleukin 8 (IL-8).
Previously, we demonstrated a role for c-Src kinase activation in Ox-PAPC-induced IL-8
transcription. In this study, we have examined the mechanism regulating IL-8 transcription by
Ox-PAPC downstream of c-Src. Our findings demonstrate an important role for JAK2 in the …
component phospholipid, 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine,
induce endothelial cells (EC) to synthesize chemotactic factors, such as interleukin 8 (IL-8).
Previously, we demonstrated a role for c-Src kinase activation in Ox-PAPC-induced IL-8
transcription. In this study, we have examined the mechanism regulating IL-8 transcription by
Ox-PAPC downstream of c-Src. Our findings demonstrate an important role for JAK2 in the …