Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors

BM Wehrli, W Huang, B De Crombrugghe, AG Ayala… - Human pathology, 2003 - Elsevier
Over the last decade, a number of [ldquo] master regulator [rdquo] genes that control distinct
pathways of mesenchymal differentiation have been discovered. These genes are
expressed early during embryogenesis and initiate a cascade of gene expression
responsible for specific cell lineage commitment. Thus, identification of their products may
allow the classification of seemingly primitive, morphologically uncommitted tumors such as
small blue round cell tumors. The transcription factor Sox9 has been demonstrated to be a …