Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes
Accumulation of extracellular amyloid β peptide (Aβ), generated from amyloid precursor
protein (APP) processing by β-and γ-secretases, is toxic to neurons and is central to the
pathogenesis of Alzheimer disease. Production of Aβ from APP is greatly affected by the
subcellular localization and trafficking of APP. Here we have identified a novel intracellular
adaptor protein, sorting nexin 17 (SNX17), that binds specifically to the APP cytoplasmic
domain via the YXNPXY motif that has been shown previously to bind several cell surface …
protein (APP) processing by β-and γ-secretases, is toxic to neurons and is central to the
pathogenesis of Alzheimer disease. Production of Aβ from APP is greatly affected by the
subcellular localization and trafficking of APP. Here we have identified a novel intracellular
adaptor protein, sorting nexin 17 (SNX17), that binds specifically to the APP cytoplasmic
domain via the YXNPXY motif that has been shown previously to bind several cell surface …