The stomach hormone, ghrelin, which is released during food restriction, provides a link
between circulating energy state and adaptive brain function. The maintenance of such
homeostatic systems is essential for an organism to survive and thrive, and accumulating
evidence points to ghrelin being a key regulator of adult hippocampal neurogenesis and
memory function. Aberrant neurogenesis is linked to cognitive decline in aging and
neurodegeneration. Therefore, identifying endogenous metabolic factors that regulate new …