Collapsing focal segmental glomerulosclerosis (FSGS) is a distinct clinicopathologic entity
seen most commonly in young African American patients who present with renal
insufficiency and nephrotic syndrome. The only epidemiologic factor previously linked to
collapsing FSGS is HIV infection. Here clinicopathologic findings are reported for a
distinctive population of seven patients, who were older, Caucasian, and HIV negative and
developed collapsing FSGS during active treatment of malignancy (multiple myeloma in six …