Tissue-specific differences in mitochondrial activity and biogenesis
E Fernández-Vizarra, JA Enríquez, A Pérez-Martos… - Mitochondrion, 2011 - Elsevier
Each cell type develops and maintains a specific oxidative phosphorylation (OXPHOS)
capacity to satisfy its metabolic and energetic demands. This implies that there are
differences between tissues in mitochondrial number, function, protein composition and
morphology. The OXPHOS system biogenesis requires the coordinated expression of both
mitochondrial and nuclear genomes. Mitochondrial DNA (mtDNA) expression can be
regulated at different levels (replication, transcription, translation and post-translational …
capacity to satisfy its metabolic and energetic demands. This implies that there are
differences between tissues in mitochondrial number, function, protein composition and
morphology. The OXPHOS system biogenesis requires the coordinated expression of both
mitochondrial and nuclear genomes. Mitochondrial DNA (mtDNA) expression can be
regulated at different levels (replication, transcription, translation and post-translational …