[HTML][HTML] Association between the magnitude of intravenous busulfan exposure and development of hepatic veno-occlusive disease in children and young adults …

T Bognār, IH Bartelink, TCG Egberts… - … and Cellular Therapy, 2022 - Elsevier
Intravenous busulfan is widely used as part of myeloablative conditioning regimens in
children and young adults undergoing allogeneic hematopoietic cell transplantation (HCT).
Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a serious
clinical problem observed with busulfan-based conditioning HCT. The development of
VOD/SOS may be associated with busulfan exposure. Getting more insight into the
association between busulfan exposure and the development of VOD/SOS enables further …