[HTML][HTML] Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family
E Torban, HJ Wang, N Groulx, P Gros - Journal of Biological Chemistry, 2004 - ASBMB
Mammalian Vangl1 and Vangl2 are highly conserved membrane proteins that have evolved
from a single ancestral protein Strabismus/Van Gogh found in Drosophila. Mutations in the
Vangl2 gene cause a neural tube defect (craniorachischisis) characteristic of the looptail
(Lp) mouse. Studies in model organisms indicate that Vangl proteins play a key
developmental role in establishing planar cell polarity (PCP) and in regulating convergent
extension (CE) movements during embryogenesis. The role of Vangl1 in these processes is …
from a single ancestral protein Strabismus/Van Gogh found in Drosophila. Mutations in the
Vangl2 gene cause a neural tube defect (craniorachischisis) characteristic of the looptail
(Lp) mouse. Studies in model organisms indicate that Vangl proteins play a key
developmental role in establishing planar cell polarity (PCP) and in regulating convergent
extension (CE) movements during embryogenesis. The role of Vangl1 in these processes is …