Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation
E Torban, HJ Wang, AM Patenaude… - Gene Expression …, 2007 - Elsevier
Loop-tail (Lp) mice show a very severe neural tube defect, craniorachischisis, which is
caused by mis-sense mutations in the Vangl2 gene. The membrane protein Vangl2 belongs
to a highly conserved group of proteins that regulate planar polarity in certain epithelia, and
that are also important for convergent extension movements during gastrulation and
neurulation. A specific anti-Vangl2 antiserum was produced and used to examine the tissue,
cell type, and sub-cellular localization of Vangl2 during embryogenesis. Vangl2 protein is …
caused by mis-sense mutations in the Vangl2 gene. The membrane protein Vangl2 belongs
to a highly conserved group of proteins that regulate planar polarity in certain epithelia, and
that are also important for convergent extension movements during gastrulation and
neurulation. A specific anti-Vangl2 antiserum was produced and used to examine the tissue,
cell type, and sub-cellular localization of Vangl2 during embryogenesis. Vangl2 protein is …