[HTML][HTML] Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression
MLS Lindegaard, P Damm, ER Mathiesen… - Journal of lipid …, 2006 - ASBMB
Maternal diabetes can cause fetal macrosomia and increased risk of obesity, diabetes, and
cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid
transport could be involved, the impact of maternal type 1 diabetes on molecular
mechanisms for lipid transport in placenta is largely unknown. To examine whether maternal
type 1 diabetes affects placental lipid metabolism, we measured lipids and mRNA
expression of lipase-encoding genes in placentas from women with type 1 diabetes (n= 27) …
cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid
transport could be involved, the impact of maternal type 1 diabetes on molecular
mechanisms for lipid transport in placenta is largely unknown. To examine whether maternal
type 1 diabetes affects placental lipid metabolism, we measured lipids and mRNA
expression of lipase-encoding genes in placentas from women with type 1 diabetes (n= 27) …