[HTML][HTML] Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling
PC Kienesberger, D Lee, T Pulinilkunnil… - Journal of Biological …, 2009 - ASBMB
Triacylglycerol accumulation in insulin target tissues is associated with insulin resistance.
Paradoxically, mice with global targeted deletion of adipose triglyceride lipase (ATGL), the
rate-limiting enzyme in triacylglycerol hydrolysis, display improved glucose tolerance and
insulin sensitivity despite triacylglycerol accumulation in multiple tissues. To determine the
molecular mechanisms for this phenotype, ATGL-deficient (ATGL−/−) and wild-type mice
were injected with saline or insulin (10 units/kg, intraperitoneally), and then phosphorylation …
Paradoxically, mice with global targeted deletion of adipose triglyceride lipase (ATGL), the
rate-limiting enzyme in triacylglycerol hydrolysis, display improved glucose tolerance and
insulin sensitivity despite triacylglycerol accumulation in multiple tissues. To determine the
molecular mechanisms for this phenotype, ATGL-deficient (ATGL−/−) and wild-type mice
were injected with saline or insulin (10 units/kg, intraperitoneally), and then phosphorylation …