[HTML][HTML] The impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes
C Chitraju, M Trötzmüller, J Hartler, H Wolinski… - Journal of Lipid …, 2013 - ASBMB
We showed earlier that nutritional stress like starvation or high-fat diet resulted in phenotypic
changes in the lipidomes of hepatocyte lipid droplets (LDs), representative for the
pathophysiological status of the mouse model. Here we extend our former study by adding
genetic stress due to knockout (KO) of adipocyte triglyceride lipase (ATGL), the rate limiting
enzyme in LD lipolysis. An intervention trial for 6 weeks with male wild-type (WT) and ATGL-
KO mice was carried out; both genotypes were fed lab chow or were exposed to short-time …
changes in the lipidomes of hepatocyte lipid droplets (LDs), representative for the
pathophysiological status of the mouse model. Here we extend our former study by adding
genetic stress due to knockout (KO) of adipocyte triglyceride lipase (ATGL), the rate limiting
enzyme in LD lipolysis. An intervention trial for 6 weeks with male wild-type (WT) and ATGL-
KO mice was carried out; both genotypes were fed lab chow or were exposed to short-time …