[HTML][HTML] Calcium-independent phospholipases A2 and their roles in biological processes and diseases
Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s,
the iPLA 2 s are more recently described and details of their expression and roles in
biological functions are rapidly emerging. The iPLA 2 s or patatin-like phospholipases
(PNPLAs) are intracellular enzymes that do not require Ca 2+ for activity, and contain lipase
(GXSXG) and nucleotide-binding (GXGXXG) consensus sequences. Though nine PNPLAs …
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s,
the iPLA 2 s are more recently described and details of their expression and roles in
biological functions are rapidly emerging. The iPLA 2 s or patatin-like phospholipases
(PNPLAs) are intracellular enzymes that do not require Ca 2+ for activity, and contain lipase
(GXSXG) and nucleotide-binding (GXGXXG) consensus sequences. Though nine PNPLAs …