[HTML][HTML] CGI-58 interacts with perilipin and is localized to lipid droplets: possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome
T Yamaguchi, N Omatsu, S Matsushita… - Journal of Biological …, 2004 - ASBMB
Lipid droplets (LDs) are a class of ubiquitous cellular organelles that are involved in lipid
storage and metabolism. Although the mechanisms of the biogenesis of LDs are still
unclear, a set of proteins called the PAT domain family have been characterized as factors
associating with LDs. Perilipin, a member of this family, is expressed exclusively in the
adipose tissue and regulates the breakdown of triacylglycerol in LDs via its phosphorylation.
In this study, we used a yeast two-hybrid system to examine the potential function of …
storage and metabolism. Although the mechanisms of the biogenesis of LDs are still
unclear, a set of proteins called the PAT domain family have been characterized as factors
associating with LDs. Perilipin, a member of this family, is expressed exclusively in the
adipose tissue and regulates the breakdown of triacylglycerol in LDs via its phosphorylation.
In this study, we used a yeast two-hybrid system to examine the potential function of …