[HTML][HTML] Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI …
FPW Radner, IE Streith, G Schoiswohl… - Journal of biological …, 2010 - ASBMB
Comparative gene identification-58 (CGI-58), also designated as α/β-hydrolase domain
containing-5 (ABHD-5), is a lipid droplet-associated protein that activates adipose
triglyceride lipase (ATGL) and acylates lysophosphatidic acid. Activation of ATGL initiates
the hydrolytic catabolism of cellular triacylglycerol (TG) stores to glycerol and nonesterified
fatty acids. Mutations in both ATGL and CGI-58 cause" neutral lipid storage disease"
characterized by massive accumulation of TG in various tissues. The analysis of CGI-58 …
containing-5 (ABHD-5), is a lipid droplet-associated protein that activates adipose
triglyceride lipase (ATGL) and acylates lysophosphatidic acid. Activation of ATGL initiates
the hydrolytic catabolism of cellular triacylglycerol (TG) stores to glycerol and nonesterified
fatty acids. Mutations in both ATGL and CGI-58 cause" neutral lipid storage disease"
characterized by massive accumulation of TG in various tissues. The analysis of CGI-58 …