Evaluation of platelet responses in transfusion-related acute lung injury (TRALI)
EANZ van der Laan, S van der Velden… - Transfusion Medicine …, 2020 - Elsevier
Platelets are versatile cells which are capable of eliciting nonhemostatic immune functions,
especially under inflammatory conditions. Depending on the specific setting, platelets may
be either protective or pathogenic in acute lung injury and acute respiratory distress
syndrome (ARDS). Their role in transfusion-related acute lung injury (TRALI) is less well
defined; however, it has been hypothesized that recipient platelets and transfused platelets
both play a pathogenic role in TRALI. Overall, despite conflicting findings, it appears that …
especially under inflammatory conditions. Depending on the specific setting, platelets may
be either protective or pathogenic in acute lung injury and acute respiratory distress
syndrome (ARDS). Their role in transfusion-related acute lung injury (TRALI) is less well
defined; however, it has been hypothesized that recipient platelets and transfused platelets
both play a pathogenic role in TRALI. Overall, despite conflicting findings, it appears that …