[BOOK][B] Sphingolipids in acute lung injury
S Uhlig, Y Yang - 2013 - Springer
S Uhlig, Y Yang
2013•SpringerAcute lung injury is a life-threatening disease that is characterized by pulmonary
inflammation, loss of barrier functions, and hypoxemia. Sphingolipids are critically involved
in the disease process that they can both expedite and extenuate: They expedite
inflammation by promoting chemotaxis (neutral sphingomyelinase), increased endothelial
permeability (acid sphingomyelinase, S1P 3-receptors), increased epithelial permeability
(S1P 2-and S1P 3-receptors), and delaying neutrophil apoptosis (neutral sphingomyelinase …
inflammation, loss of barrier functions, and hypoxemia. Sphingolipids are critically involved
in the disease process that they can both expedite and extenuate: They expedite
inflammation by promoting chemotaxis (neutral sphingomyelinase), increased endothelial
permeability (acid sphingomyelinase, S1P 3-receptors), increased epithelial permeability
(S1P 2-and S1P 3-receptors), and delaying neutrophil apoptosis (neutral sphingomyelinase …
Abstract
Acute lung injury is a life-threatening disease that is characterized by pulmonary inflammation, loss of barrier functions, and hypoxemia. Sphingolipids are critically involved in the disease process that they can both expedite and extenuate: They expedite inflammation by promoting chemotaxis (neutral sphingomyelinase), increased endothelial permeability (acid sphingomyelinase, S1P3-receptors), increased epithelial permeability (S1P2- and S1P3-receptors), and delaying neutrophil apoptosis (neutral sphingomyelinase, S1P1-receptors). They extenuate inflammation by attenuating chemotaxis (S1P) and by stabilizing the endothelial and the epithelial barrier (S1P1-receptor). This chapter discusses the multiple roles and therapeutic options that sphingolipids offer with respect to acute lung injury.
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