[HTML][HTML] Animal models for COVID-19

C Muñoz-Fontela, WE Dowling, SGP Funnell, PS Gsell… - Nature, 2020 - nature.com
C Muñoz-Fontela, WE Dowling, SGP Funnell, PS Gsell, AX Riveros-Balta, RA Albrecht…
Nature, 2020nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of
coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the
introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei
province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has
infected more than 30 million people and has caused more than 950,000 deaths. As
humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to …
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.
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