Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer's …
Aims The sporadic and late-onset form of Alzheimer's disease (AD) constitutes the most
common form of dementia. This non-familiar form could be a consequence of metabolic
syndrome, characterized by obesity and the development of a brain-specific insulin
resistance known as type III diabetes. This work demonstrates the development of a
significant AD-like neuropathology due to these metabolic alterations. Methods C57BL/6J
mice strain were divided into two groups, one fed with a diet rich in palmitic acid (high-fat …
common form of dementia. This non-familiar form could be a consequence of metabolic
syndrome, characterized by obesity and the development of a brain-specific insulin
resistance known as type III diabetes. This work demonstrates the development of a
significant AD-like neuropathology due to these metabolic alterations. Methods C57BL/6J
mice strain were divided into two groups, one fed with a diet rich in palmitic acid (high-fat …