Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients: a case series
Annals of internal medicine, 2021•acpjournals.org
Background: The antibody response after 2 doses of an mRNA vaccine against SARS-CoV-
2 is excellent in the general population (1), but the response is different in recipients of solid
organ transplants. For example, we have found markedly attenuated antibody responses in
transplant recipients after 2 doses of an mRNA vaccine against SARS-CoV-2 (2). In addition,
reports of COVID-19 breakthrough infections in vaccinated transplant recipients (3) have
prompted interest in administering additional doses of vaccine. Objective: To describe …
2 is excellent in the general population (1), but the response is different in recipients of solid
organ transplants. For example, we have found markedly attenuated antibody responses in
transplant recipients after 2 doses of an mRNA vaccine against SARS-CoV-2 (2). In addition,
reports of COVID-19 breakthrough infections in vaccinated transplant recipients (3) have
prompted interest in administering additional doses of vaccine. Objective: To describe …
Background: The antibody response after 2 doses of an mRNA vaccine against SARS-CoV-2 is excellent in the general population (1), but the response is different in recipients of solid organ transplants. For example, we have found markedly attenuated antibody responses in transplant recipients after 2 doses of an mRNA vaccine against SARS-CoV-2 (2). In addition, reports of COVID-19 breakthrough infections in vaccinated transplant recipients (3) have prompted interest in administering additional doses of vaccine.
Objective: To describe antibody responses and vaccine reactions in recipients of solid organ transplants who had a suboptimal response to standard vaccination and subsequently received a third dose of vaccine between 20 March 2021 and 10 May 2021.
Case Series: This study was approved by the Johns Hopkins institutional review board, and participants provided informed consent.
acpjournals.org
