Critical limb ischemia: current challenges and future prospects

L Uccioli, M Meloni, V Izzo, L Giurato… - Vascular health and …, 2018 - Taylor & Francis
L Uccioli, M Meloni, V Izzo, L Giurato, S Merolla, R Gandini
Vascular health and risk management, 2018Taylor & Francis
Critical limb ischemia (CLI) is considered the most severe pattern of peripheral artery
disease. It is defined by the presence of chronic ischemic rest pain, ulceration or gangrene
attributable to the occlusion of peripheral arterial vessels. It is associated with a high risk of
major amputation, cardiovascular events and death. In this review, we presented a complete
overview about physiopathology, diagnosis and holistic management of CLI.
Revascularization is the first-line treatment, but several challenging cases are not treatable …
Critical limb ischemia (CLI) is considered the most severe pattern of peripheral artery disease. It is defined by the presence of chronic ischemic rest pain, ulceration or gangrene attributable to the occlusion of peripheral arterial vessels. It is associated with a high risk of major amputation, cardiovascular events and death. In this review, we presented a complete overview about physiopathology, diagnosis and holistic management of CLI. Revascularization is the first-line treatment, but several challenging cases are not treatable by conventional techniques. Unconventional techniques for the treatment of complex below-the-knee arterial disease are described. Furthermore, the state-of-the-art on gene and cell therapy for the treatment of no-option patients is reported.
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