Acute phase reactants in allergic airway disease

S Büyüköztürk, AA Gelincik, S Genç… - The Tohoku journal of …, 2004 - jstage.jst.go.jp
S Büyüköztürk, AA Gelincik, S Genç, H Koçak, Y Öneriyidogan, S Erden, M Dal, B Çolakoglu
The Tohoku journal of experimental medicine, 2004jstage.jst.go.jp
RESULTS In the rhinitis and asthma groups, there were great differences in the CRP (0.44-
44.92 mg/100 ml) and SAA (9.59-932 μg/ml) concentrations of patients in contrast to
fibrinogen, which was rather stable (Table 1). Although very high CRP levels were noticed in
patients with rhinitis and asthma, the mean CRP and fibrinogen values in these groups were
not significantly different when compared to the control group. However, the mean SAA
levels of both groups were found to be significantly higher than that of the control group (p …
RESULTS
In the rhinitis and asthma groups, there were great differences in the CRP (0.44-44.92 mg/100 ml) and SAA (9.59-932 μg/ml) concentrations of patients in contrast to fibrinogen, which was rather stable (Table 1). Although very high CRP levels were noticed in patients with rhinitis and asthma, the mean CRP and fibrinogen values in these groups were not significantly different when compared to the control group. However, the mean SAA levels of both groups were found to be significantly higher than that of the control group (p= 0.002, p= 0.02 respectively). As the allergic rhinitis and asthma have been regarded to be close entities by most authors, the two patient groups were combined as one and similar results were obtained when compared to the control group (p= ly studied acute phase proteins, is shown to stimulate the release of inflammatory cytokines in monocytes. Another major acute-phase protein, serum amyloid A (SAA) is also demonstrated to cause adhesion and chemotaxis of phagocytic cells and lymphocytes in atherosclerotic plaques. Asthma is considered as an inflammatory disease of airways. According to recent data, asthma and rhinitis are closely linked entities and they together define the unique inflammatory disorder,“United Airway Disease”(Passalacqua and Canonica 2002), or “Combined Allergic Rhinitis Asthma Syndrome.” Some inflammatory markers, such as eosinophils, interleukin-5 (IL-5), eotaxin, eosinophilic cationic protein (ECP), and nitric oxide (NO) have been used to demonstrate the presence and persistance of airway inflammation. In present study, we aimed to investigate the serum and plasma concentrations of three acute phase proteins, CRP, fibrinogen and SAA, in patients with allergic rhinitis and with asthma.
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