[HTML][HTML] Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling

S Bena, V Brancaleone, JM Wang, M Perretti… - Journal of Biological …, 2012 - ASBMB
Understanding how proresolving agonists selectively activate FPR2/ALX is a crucial step in
the clarification of proresolution molecular networks that can be harnessed for the design of
novel therapeutics for inflammatory disease. FPR2/ALX, a G protein-coupled receptor
belonging to the formyl peptide receptor (FPR) family, conveys the biological functions of a
variety of ligands, including the proresolution mediators annexin A1 (AnxA1) and lipoxin A 4,
as well as the activating and proinflammatory protein serum amyloid A. FPR2/ALX is the …