The effects of Lipoxin A4 on airway responses in asthmatic subjects 1-3

PE Christie, BW Spur, T Lee - Am Rev Respir Dis, 1992 - atsjournals.org
PE Christie, BW Spur, T Lee
Am Rev Respir Dis, 1992atsjournals.org
This study was performed to determine whether IIpoxln A.(LXA.) Inhalation in asthmatic
subjects has an effect on airways response. Eight subjects (six asthmatic, two normal)
attended for bronchial Inhalation challenge with LXA•. In three of these SUbjects (two
asthmatics, one normal) blood pressure, pulse, and symptoms before and after challenge
were recorded. Subsequently five male patients with mild asthma (22 to 34 yr of age)
reattended for bronchial Inhalation challenge with either leukotrlene C.(LTC.) or the …
Summary
This study was performed to determine whether IIpoxln A.(LXA.) Inhalation in asthmatic subjects has an effect on airways response. Eight subjects (six asthmatic, two normal) attended for bronchial Inhalation challenge with LXA•. In three of these SUbjects (two asthmatics, one normal) blood pressure, pulse, and symptoms before and after challenge were recorded. Subsequently five male patients with mild asthma (22 to 34 yr of age) reattended for bronchial Inhalation challenge with either leukotrlene C.(LTC.) or the combination of LTC. and 1 x 10-'M LXA•. After
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