Folylpoly-γ-glutamate synthetase: a key determinant of folate homeostasis and antifolate resistance in cancer

S Raz, M Stark, YG Assaraf - Drug Resistance Updates, 2016 - Elsevier
Mammalians are devoid of autonomous biosynthesis of folates and hence must obtain them
from the diet. Reduced folate cofactors are B9-vitamins which play a key role as donors of
one-carbon units in the biosynthesis of purine nucleotides, thymidylate and amino acids as
well as in a multitude of methylation reactions including DNA, RNA, histone and non-histone
proteins, phospholipids, as well as intermediate metabolites. The products of these S-
adenosylmethionine (SAM)-dependent methylations are involved in the regulation of key …