Pharmacokinetics of sucralose and acesulfame-potassium in breast milk following ingestion of diet soda
KI Rother, AC Sylvetsky, PJ Walter… - Journal of pediatric …, 2018 - journals.lww.com
KI Rother, AC Sylvetsky, PJ Walter, HM Garraffo, DA Fields
Journal of pediatric gastroenterology and nutrition, 2018•journals.lww.comObjective: The aim of this study was to determine sucralose and acesulfame-potassium (ace-
K) pharmacokinetics in breast milk following maternal ingestion of a diet soda. Methods:
Thirty-four exclusively breast-feeding women (14 normal-weight, 20 obese) consumed 12
ounces of Diet Rite Cola, sweetened with 68-mg sucralose and 41-mg ace-K, before a
standardized breakfast meal. Habitual non-nutritional sweeteners intake was assessed via a
diet questionnaire. Breast milk was collected from the same breast before beverage …
K) pharmacokinetics in breast milk following maternal ingestion of a diet soda. Methods:
Thirty-four exclusively breast-feeding women (14 normal-weight, 20 obese) consumed 12
ounces of Diet Rite Cola, sweetened with 68-mg sucralose and 41-mg ace-K, before a
standardized breakfast meal. Habitual non-nutritional sweeteners intake was assessed via a
diet questionnaire. Breast milk was collected from the same breast before beverage …
Abstract
Objective:
The aim of this study was to determine sucralose and acesulfame-potassium (ace-K) pharmacokinetics in breast milk following maternal ingestion of a diet soda.
Methods:
Thirty-four exclusively breast-feeding women (14 normal-weight, 20 obese) consumed 12 ounces of Diet Rite Cola, sweetened with 68-mg sucralose and 41-mg ace-K, before a standardized breakfast meal. Habitual non-nutritional sweeteners intake was assessed via a diet questionnaire. Breast milk was collected from the same breast before beverage ingestion and hourly for 6 hours.
Results:
Owing to one mother having extremely high concentrations, peak sucralose and acesulfame-potassium concentrations following ingestion of diet soda ranged from 4.0 to 7387.9 ng/mL (median peak 8.1 ng/mL) and 299.0 to 4764.2 ng/mL (median peak 945.3 ng/mL), respectively.
Conclusions:
Ace-K and sucralose transfer into breast milk following ingestion of a diet soda. Future research should measure concentrations after repeated exposure and determine whether chronic ingestion of sucralose and acesulfame-potassium via the breast milk has clinically relevant health consequences.
Lippincott Williams & Wilkins