Non-targeted metabolomic biomarkers and metabotypes of type 2 diabetes: A cross-sectional study of PREDIMED trial participants
M Urpi-Sarda, E Almanza-Aguilera, R Llorach… - Diabetes & …, 2019 - Elsevier
Aim To characterize the urinary metabolomic fingerprint and multi-metabolite signature
associated with type 2 diabetes (T2D), and to classify the population into metabotypes
related to T2D. Methods A metabolomics analysis using the 1 H-NMR-based, non-targeted
metabolomic approach was conducted to determine the urinary metabolomic fingerprint of
T2D compared with non-T2D participants in the PREDIMED trial. The discriminant
metabolite fingerprint was subjected to logistic regression analysis and ROC analyses to …
associated with type 2 diabetes (T2D), and to classify the population into metabotypes
related to T2D. Methods A metabolomics analysis using the 1 H-NMR-based, non-targeted
metabolomic approach was conducted to determine the urinary metabolomic fingerprint of
T2D compared with non-T2D participants in the PREDIMED trial. The discriminant
metabolite fingerprint was subjected to logistic regression analysis and ROC analyses to …