In an effort to reduce sugar consumption to prevent diabetes mellitus and cardiovascular
diseases,“sugar-free” or “no added sugar” products that substitute sugar with non-nutritive
sweeteners (NNSs)(eg, Splenda, Sweet'N Low, and Stevia) have become increasingly
popular. The use of these products during pregnancy has also increased, with
approximately 30% of pregnant women reporting intentional NNS consumption. In clinical
studies with nonpregnant participants and animal models, NNSs were shown to alter gut …