Developmental programming and diabetes–the human experience and insight from animal models
L Poston - Best Practice & Research Clinical Endocrinology & …, 2010 - Elsevier
Children born to mothers, rather than to fathers, with type 1 diabetes (type 1 DM) or type 2
diabetes (type 2 DM) may have a greater susceptibility to diabetes and obesity in later life,
inferring a role for in utero or early post-natal influences on the developing child. This review
summarises the studies contributing to this hypothesis, noting some of the controversies
including the potential for residual confounding and the influence of maternal BMI. Animal
models demonstrate that maternal hyperglycaemia leads to persistent disorders of offspring …
diabetes (type 2 DM) may have a greater susceptibility to diabetes and obesity in later life,
inferring a role for in utero or early post-natal influences on the developing child. This review
summarises the studies contributing to this hypothesis, noting some of the controversies
including the potential for residual confounding and the influence of maternal BMI. Animal
models demonstrate that maternal hyperglycaemia leads to persistent disorders of offspring …